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KMID : 0369820150450020115
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Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 2 p.115 ~ p.130
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Design, development, in vitro and in vivo evaluation of multicomponent tablet formulation for enteral delivery of atorvastatin calcium and felodipine
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Jadhav Namdeo R.
Kambar Ramesh S.
Nadaf Sameer J.
Phadatare Prashant D.
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Abstract
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Frequent occurrence, higher morbidity and mortality rate of atherosclerosis associated hypertension in elderly people shambles health care system worldwide. So the present study was deliberated to formulate and appraise rational combination, containing immediate release portion of atorvastatin calcium (ATR) and sustained release (SR) portion of felodipine (FEL) in bilayered multicomponent tablet formulation for elderly people. A 32 factorial design was used to prepare atorvastatin calcium and felodipine tablets separately. For each drug total nine batches (A1?A9 for ATR; F1?F9 for FEL) were prepared. The amount of sodium starch glycollate (X1) and lactose (X2) were used as independent variables for atorvastatin calcium and hydroxypropyl methyl cellulose 50 cps (X1) and talc (X2) for felodipine tablets. Talc being hydrophobic diluents has been tried as release retardant. On the basis of flowability, compressibility, compactibility, tensile strength and drug release, the both layers of formulation were optimized, and subsequently, bilayered multicomponent tablet formulation was prepared and evaluated. The optimized tablet formulations of atorvastatin calcium (Batch A3) released 76 % of drug after 30 min, while (Batch F8) of felodipine showed drug release up to 79 % after 10 h and followed peppas release pattern (r2 = 0.9862). The similar release pattern was noticed in the bilayered tablet formulation of atorvastatin calcium and felodipine meeting the USP requirements. Hence, it can be concluded that, the aforesaid bilayered formulation can meet the needs of those elderly people, who suffer from mild hypertension and hyperlipidemia.
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KEYWORD
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Atorvastatin calcium, Felodipine, Bilayered formulation, Hypertension
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